Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

The flavivirus methyltransferase (MTase) sequentially methylates the N7 and 2′-O positions of the viral RNA cap (GpppA-RNA → m(7)GpppA-RNA → m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor. We report here that sinefungin (SIN), an AdoMet analog, inhibits several flaviviruse...

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Detalhes bibliográficos
Main Authors: Dong, Hongping, Liu, Lihui, Zou, Gang, Zhao, Yiwei, Li, Zhong, Lim, Siew Pheng, Shi, Pei-Yong, Li, Hongmin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952261/
https://ncbi.nlm.nih.gov/pubmed/20685660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129197
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