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Structure and Function of Flavivirus NS5 Methyltransferase
The plus-strand RNA genome of flavivirus contains a 5′ terminal cap 1 structure (m(7)GpppAmG). The flaviviruses encode one methyltransferase, located at the N-terminal portion of the NS5 protein, to catalyze both guanine N-7 and ribose 2′-OH methylations during viral cap formation. Representative fl...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1866096/ https://ncbi.nlm.nih.gov/pubmed/17267492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02704-06 |
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