Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

The 5′ end of the flavivirus plus-sense RNA genome contains a type 1 cap (m(7)GpppAmG), followed by a conserved stem-loop structure. We report that nonstructural protein 5 (NS5) from four serocomplexes of flaviviruses specifically methylates the cap through recognition of the 5′ terminus of viral RN...

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Detalhes bibliográficos
Main Authors: Dong, Hongping, Ray, Debashish, Ren, Suping, Zhang, Bo, Puig-Basagoiti, Francesc, Takagi, Yuko, Ho, C. Kiong, Li, Hongmin, Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900168/
https://ncbi.nlm.nih.gov/pubmed/17301144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02455-06
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