West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

Flaviviruses encode a single methyltransferase domain that sequentially catalyzes two methylations of the viral RNA cap, GpppA-RNA→m(7)GpppA-RNA→m(7)GpppAm-RNA, by using S-adenosyl-l-methionine (SAM) as a methyl donor. Crystal structures of flavivirus methyltransferases exhibit distinct binding site...

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Detalhes bibliográficos
Main Authors: Dong, Hongping, Ren, Suping, Zhang, Bo, Zhou, Yangsheng, Puig-Basagoiti, Francesc, Li, Hongmin, Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293060/
https://ncbi.nlm.nih.gov/pubmed/18305027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-07
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