West Nile Virus 5′-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2′-O Methylations by Nonstructural Protein 5

Many flaviviruses are globally important human pathogens. Their plus-strand RNA genome contains a 5′-cap structure that is methylated at the guanine N-7 and the ribose 2′-OH positions of the first transcribed nucleotide, adenine (m(7)GpppAm). Using West Nile virus (WNV), we demonstrate, for the firs...

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Detalhes bibliográficos
Main Authors: Ray, Debashish, Shah, Aaloki, Tilgner, Mark, Guo, Yi, Zhao, Yiwei, Dong, Hongping, Deas, Tia S., Zhou, Yangsheng, Li, Hongmin, Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563844/
https://ncbi.nlm.nih.gov/pubmed/16912287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00814-06
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