Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

Flavivirus methyltransferase (MTase) is essential for viral replication. Here we report the identification of small molecules through virtual screening that putatively bind to the SAM-binding site of flavivirus MTase and inhibit its function. Six of these computationally predicted binders were ident...

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Detaylı Bibliyografya
Yayımlandı:ACS Infect Dis
Asıl Yazarlar: Brecher, Matthew, Chen, Hui, Li, Zhong, Banavali, Nilesh K., Jones, Susan A., Zhang, Jing, Kramer, Laura D., Li, Hongmin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696607/
https://ncbi.nlm.nih.gov/pubmed/26726314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00070
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