Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

Flavivirus methyltransferase (MTase) is essential for viral replication. Here we report the identification of small molecules through virtual screening that putatively bind to the SAM-binding site of flavivirus MTase and inhibit its function. Six of these computationally predicted binders were ident...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Brecher, Matthew, Chen, Hui, Li, Zhong, Banavali, Nilesh K., Jones, Susan A., Zhang, Jing, Kramer, Laura D., Li, Hongmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696607/
https://ncbi.nlm.nih.gov/pubmed/26726314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00070
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