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Evaluation of TK1 targeting carboranyl thymidine analogues as potential delivery agents for neutron capture therapy of brain tumors
In this report we describe studies with N5-2OH, a carboranyl thymidine analogue (CTA) that is a substrate for thymidine kinase 1 (TK1), using the F98 rat glioma model. In vivo BNCT studies have demonstrated that intracerebral (i.c.) osmotic pump infusion of N5-2OH yielded survival data equivalent to...
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| Udgivet i: | Appl Radiat Isot |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4685942/ https://ncbi.nlm.nih.gov/pubmed/26282567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2015.06.031 |
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