Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells

Expression of tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for self-tolerance induction and prevents autoimmunity, with each TRA being expressed in only a few mTECs. How this process is regulated in single mTECs and coordinated at the population le...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Brennecke, Philip, Reyes, Alejandro, Pinto, Sheena, Rattay, Kristin, Nguyen, Michelle, Küchler, Rita, Huber, Wolfgang, Kyewski, Bruno, Steinmetz, Lars M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675844/
https://ncbi.nlm.nih.gov/pubmed/26237553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3246
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