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Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells
Expression of tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for self-tolerance induction and prevents autoimmunity, with each TRA being expressed in only a few mTECs. How this process is regulated in single mTECs and coordinated at the population le...
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| Udgivet i: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4675844/ https://ncbi.nlm.nih.gov/pubmed/26237553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3246 |
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