Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells

Thymic central tolerance comprehensively imprints the T-cell receptor repertoire before T cells seed the periphery. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process by virtue of promiscuous expression of tissue-restricted autoantigens. The molecular regulation of this un...

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Detalhes bibliográficos
Main Authors: Tykocinski, Lars-Oliver, Sinemus, Anna, Rezavandy, Esmail, Weiland, Yanina, Baddeley, David, Cremer, Christoph, Sonntag, Stephan, Willecke, Klaus, Derbinski, Jens, Kyewski, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984162/
https://ncbi.nlm.nih.gov/pubmed/20966351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009265107
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