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Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

Promiscuous expression of tissue-restricted autoantigens in medullary thymic epithelial cells (mTECs) imposes central T cell tolerance. The molecular regulation of this unusual gene expression is not understood, in particular its delineation from cell lineage-specific gene expression control remains...

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Bibliografiske detaljer
Main Authors: Derbinski, Jens, Pinto, Sheena, Rösch, Stefanie, Hexel, Klaus, Kyewski, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206592/
https://ncbi.nlm.nih.gov/pubmed/18180458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707486105
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