Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity

Promiscuous expression of numerous tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential to safeguard self-tolerance. A distinct feature of promiscuous gene expression is its mosaic pattern (i.e., at a given time, each self-antigen is expressed only in 1–3%...

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Detalhes bibliográficos
Main Authors: Pinto, Sheena, Michel, Chloé, Schmidt-Glenewinkel, Hannah, Harder, Nathalie, Rohr, Karl, Wild, Stefan, Brors, Benedikt, Kyewski, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773787/
https://ncbi.nlm.nih.gov/pubmed/23980163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308311110
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