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Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
Promiscuous expression of numerous tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential to safeguard self-tolerance. A distinct feature of promiscuous gene expression is its mosaic pattern (i.e., at a given time, each self-antigen is expressed only in 1–3%...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773787/ https://ncbi.nlm.nih.gov/pubmed/23980163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308311110 |
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