The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

YAP and TAZ are transcriptional co-activators and function as the major effectors of the Hippo tumor suppressor pathway, which controls cell growth, tissue homeostasis, and organ size. Here we show that YAP/TAZ play an essential role in amino acid-induced mTORC1 activation, particularly under nutrie...

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Bibliografiske detaljer
Udgivet i:Cell Res
Main Authors: Hansen, Carsten Gram, Ng, Yuen Lam Dora, Lam, Wai-Ling Macrina, Plouffe, Steven W, Guan, Kun-Liang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670996/
https://ncbi.nlm.nih.gov/pubmed/26611634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.140
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