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The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1
YAP and TAZ are transcriptional co-activators and function as the major effectors of the Hippo tumor suppressor pathway, which controls cell growth, tissue homeostasis, and organ size. Here we show that YAP/TAZ play an essential role in amino acid-induced mTORC1 activation, particularly under nutrie...
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| Pubblicato in: | Cell Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4670996/ https://ncbi.nlm.nih.gov/pubmed/26611634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.140 |
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