Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

Enzymes in heteromeric, allosterically regulated complexes catalyze a rich array of chemical reactions. Separating the subunits of such complexes, however, often severely attenuates their catalytic activities, because they can no longer be activated by their protein partners. We used directed evolut...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Buller, Andrew R., Brinkmann-Chen, Sabine, Romney, David K., Herger, Michael, Murciano-Calles, Javier, Arnold, Frances H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664345/
https://ncbi.nlm.nih.gov/pubmed/26553994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516401112
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