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Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

Enzymes in heteromeric, allosterically regulated complexes catalyze a rich array of chemical reactions. Separating the subunits of such complexes, however, often severely attenuates their catalytic activities, because they can no longer be activated by their protein partners. We used directed evolut...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Buller, Andrew R., Brinkmann-Chen, Sabine, Romney, David K., Herger, Michael, Murciano-Calles, Javier, Arnold, Frances H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664345/
https://ncbi.nlm.nih.gov/pubmed/26553994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516401112
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