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A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation

Naturally occurring enzyme homologs often display highly divergent activity with non-natural substrates. Exploiting this diversity with enzymes engineered for new or altered function, however, is laborious because the engineering must be replicated for each homolog. We demonstrate that a small set o...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Murciano-Calles, Javier, Romney, David K., Brinkmann-Chen, Sabine, Buller, Andrew R., Arnold, Frances H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014574/
https://ncbi.nlm.nih.gov/pubmed/27510733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201606242
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