Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage

Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide. Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional changes in the redox pathways in the liver, including downregulation of superoxide dismutase 1 (Sod1). Sod1(−/−) mi...

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Bibliografske podrobnosti
izdano v:Immunity
Main Authors: Bhattacharya, Anannya, Hegazy, Ahmed N., Deigendesch, Nikolaus, Kosack, Lindsay, Cupovic, Jovana, Kandasamy, Richard K., Hildebrandt, Andrea, Merkler, Doron, Kühl, Anja A., Vilagos, Bojan, Schliehe, Christopher, Panse, Isabel, Khamina, Kseniya, Baazim, Hatoon, Arnold, Isabelle, Flatz, Lukas, Xu, Haifeng C., Lang, Philipp A., Aderem, Alan, Takaoka, Akinori, Superti-Furga, Giulio, Colinge, Jacques, Ludewig, Burkhard, Löhning, Max, Bergthaler, Andreas
Format: Artigo
Jezik:Inglês
Izdano: The Authors. Published by Elsevier Inc. 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658338/
https://ncbi.nlm.nih.gov/pubmed/26588782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.10.013
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