The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

Immune responses are tightly regulated to ensure efficient pathogen clearance while avoiding tissue damage. Here we report that SET domain bifurcated 2 (Setdb2) was the only protein lysine methyltransferase induced during influenza virus infection. Setdb2 expression depended on type-I interferon sig...

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Gepubliceerd in:Nat Immunol
Hoofdauteurs: Schliehe, Christopher, Flynn, Elizabeth K., Vilagos, Bojan, Richson, Udochuku, Swaminanthan, Savitha, Bosnjak, Berislav, Bauer, Lisa, Kandasamy, Richard K., Griesshammer, Isabel M., Kosack, Lindsay, Schmitz, Frank, Litvak, Vladimir, Sissons, James, Lercher, Alexander, Bhattacharya, Anannya, Khamina, Kseniya, Trivett, Anna L., Tessarollo, Lino, Mesteri, Ildiko, Hladik, Anastasiya, Merkler, Doron, Kubicek, Stefan, Knapp, Sylvia, Epstein, Michelle M., Symer, David E., Aderem, Alan, Bergthaler, Andreas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320687/
https://ncbi.nlm.nih.gov/pubmed/25419628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3046
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