How do mammalian transposons induce genetic variation? A conceptual framework: The age, structure, allele frequency and genome context of transposable elements may define their wid...

por Akagi, Keiko, Li, Jingfeng, Symer, David E.
Publicado en Bioessays (2013)

Roles of retrotransposons in benign and malignant hematologic disease

por Schneider, Anna M., Duffield, Amy S., Symer, David E., Burns, Kathleen H.
Publicado 2009

Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition

por Akagi, Keiko, Li, Jingfeng, Stephens, Robert M., Volfovsky, Natalia, Symer, David E.
Publicado 2008

An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition

por Li, Jingfeng, Kannan, Manoj, Trivett, Anna L., Liao, Hongling, Wu, Xiaolin, Akagi, Keiko, Symer, David E.
Publicado 2014

MouseIndelDB: a database integrating genomic indel polymorphisms that distinguish mouse strains

por Akagi, Keiko, Stephens, Robert M., Li, Jingfeng, Evdokimov, Evgenji, Kuehn, Michael R., Volfovsky, Natalia, Symer, David E.
Publicado 2010

Oral HPV infection before and after treatment for HPV16-positive and negative head and neck squamous cell carcinoma

por Agrawal, Yuri, Koch, Wayne M., Xiao, Weihong, Westra, William H., Trivett, Anna L., Symer, David E., Gillison, Maura L.
Publicado 2008

Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma

por Broutian, Tatevik R., Jiang, Bo, Li, Jingfeng, Akagi, Keiko, Gui, Shanying, Zhou, Zhengqiu, Xiao, Weihong, Symer, David E., Gillison, Maura L.
Publicado en Cancer Lett (2020)

The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice

por Billington, Charles J., Ng, Brandon, Forsman, Cynthia, Schmidt, Brian, Bagchi, Anindya, Symer, David E., Schotta, Gunnar, Gopalakrishnan, Rajaram, Sarver, Aaron L., Petryk, Anna
Publicado 2011

Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity

por Suarez-Kelly, Lorena P., Akagi, Keiko, Reeser, Julie W., Samorodnitsky, Eric, Reeder, Matthew, Smith, Amy, Roychowdhury, Sameek, Symer, David E., Carson, William E.
Publicado en Cold Spring Harb Mol Case Stud (2018)

Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR

por Van Duyne, Rachel, Easley, Rebecca, Wu, Weilin, Berro, Reem, Pedati, Caitlin, Klase, Zachary, Kehn-Hall, Kylene, Flynn, Elizabeth K, Symer, David E, Kashanchi, Fatah
Publicado 2008

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition

por Tomsic, Jerneja, He, Huiling, Akagi, Keiko, Liyanarachchi, Sandya, Pan, Qun, Bertani, Blake, Nagy, Rebecca, Symer, David E., Blencowe, Benjamin J., Chapelle, Albert de la
Publicado en Sci Rep (2015)

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

por Warburton, Alix, Redmond, Catherine J., Dooley, Katharine E., Fu, Haiqing, Gillison, Maura L., Akagi, Keiko, Symer, David E., Aladjem, Mirit I., McBride, Alison A.
Publicado en PLoS Genet (2018)

Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration

por Kannan, Manoj, Li, Jingfeng, Fritz, Sarah E., Husarek, Kathryn E., Sanford, Jonathan C., Sullivan, Teresa L., Tiwary, Pawan Kumar, An, Wenfeng, Boeke, Jef D., Symer, David E.
Publicado en Mob DNA (2017)

Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance

por Li, Jingfeng, Akagi, Keiko, Hu, Yongjun, Trivett, Anna L., Hlynialuk, Christopher J.W., Swing, Deborah A., Volfovsky, Natalia, Morgan, Tamara C., Golubeva, Yelena, Stephens, Robert M., Smith, David E., Symer, David E.
Publicado 2012

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice

por Refaey, Mona El, Xu, Li, Gao, Yandi, Canan, Benjamin, Adesanya, T.M. Ayodele, Warner, Sarah C., Akagi, Keiko, Symer, David E., Mohler, Peter J., Ma, Jianjie, Janssen, Paul M.L., Han, Renzhi
Publicado en Circ Res (2017)

Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer

por He, Huiling, Li, Wei, Liyanarachchi, Sandya, Srinivas, Mukund, Wang, Yanqiang, Akagi, Keiko, Wang, Yao, Wu, Dayong, Wang, Qianben, Jin, Victor, Symer, David E., Shen, Rulong, Phay, John, Nagy, Rebecca, de la Chapelle, Albert
Publicado en Proc Natl Acad Sci U S A (2015)

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

por Akagi, Keiko, Li, Jingfeng, Broutian, Tatevik R., Padilla-Nash, Hesed, Xiao, Weihong, Jiang, Bo, Rocco, James W., Teknos, Theodoros N., Kumar, Bhavna, Wangsa, Danny, He, Dandan, Ried, Thomas, Symer, David E., Gillison, Maura L.
Publicado 2014

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma

por Starrett, Gabriel J., Marcelus, Christina, Cantalupo, Paul G., Katz, Joshua P., Cheng, Jingwei, Akagi, Keiko, Thakuria, Manisha, Rabinowits, Guilherme, Wang, Linda C., Symer, David E., Pipas, James M., Harris, Reuben S., DeCaprio, James A.
Publicado en mBio (2017)

Identification of Rare Variants Predisposing to Thyroid Cancer

por Wang, Yanqiang, Liyanarachchi, Sandya, Miller, Katherine E., Nieminen, Taina T., Comiskey, Daniel F., Li, Wei, Brock, Pamela, Symer, David E., Akagi, Keiko, DeLap, Katherine E., He, Huiling, Koboldt, Daniel C., de la Chapelle, Albert
Publicado en Thyroid (2019)

Human papillomavirus and the landscape of secondary genetic alterations in oral cancers

por Gillison, Maura L., Akagi, Keiko, Xiao, Weihong, Jiang, Bo, Pickard, Robert K.L., Li, Jingfeng, Swanson, Benjamin J., Agrawal, Amit D., Zucker, Mark, Stache-Crain, Birgit, Emde, Anne-Katrin, Geiger, Heather M., Robine, Nicolas, Coombes, Kevin R., Symer, David E.
Publicado en Genome Res (2019)