Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV...

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Detalhes bibliográficos
Main Authors: Akagi, Keiko, Li, Jingfeng, Broutian, Tatevik R., Padilla-Nash, Hesed, Xiao, Weihong, Jiang, Bo, Rocco, James W., Teknos, Theodoros N., Kumar, Bhavna, Wangsa, Danny, He, Dandan, Ried, Thomas, Symer, David E., Gillison, Maura L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912410/
https://ncbi.nlm.nih.gov/pubmed/24201445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.164806.113
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