HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in HPV-associated cancers. Integration is random, and each site is unique depending on how and where the virus integrates. We recently showed that tandemly integrated HPV16 could result in the formation of a super-en...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Warburton, Alix, Redmond, Catherine J., Dooley, Katharine E., Fu, Haiqing, Gillison, Maura L., Akagi, Keiko, Symer, David E., Aladjem, Mirit I., McBride, Alison A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798845/
https://ncbi.nlm.nih.gov/pubmed/29364907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007179
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