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HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in HPV-associated cancers. Integration is random, and each site is unique depending on how and where the virus integrates. We recently showed that tandemly integrated HPV16 could result in the formation of a super-en...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS Genet
मुख्य लेखकों: Warburton, Alix, Redmond, Catherine J., Dooley, Katharine E., Fu, Haiqing, Gillison, Maura L., Akagi, Keiko, Symer, David E., Aladjem, Mirit I., McBride, Alison A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798845/
https://ncbi.nlm.nih.gov/pubmed/29364907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007179
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