HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in HPV-associated cancers. Integration is random, and each site is unique depending on how and where the virus integrates. We recently showed that tandemly integrated HPV16 could result in the formation of a super-en...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Warburton, Alix, Redmond, Catherine J., Dooley, Katharine E., Fu, Haiqing, Gillison, Maura L., Akagi, Keiko, Symer, David E., Aladjem, Mirit I., McBride, Alison A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798845/
https://ncbi.nlm.nih.gov/pubmed/29364907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007179
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