[carbonyl-(11)C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(11)C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain

INTRODUCTION: Metabotropic glutamate subtype receptor 1 (mGluR1) is implicated in several neuropsychiatric disorders and is a target for drug development. [(18)F]FIMX ([(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide) is an effective radioligand for imaging brain m...

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Publicat a:Nucl Med Biol
Autors principals: Hong, Jinsoo, Lu, Shuiyu, Xu, Rong, Liow, Jeih-San, Woock, Alicia E., Jenko, Kimberly J., Gladding, Robert L., Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658304/
https://ncbi.nlm.nih.gov/pubmed/26320813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2015.07.006
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