PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative motor neuron disorder. Genetic studies have linked mutation of the gene SOD1 to ALS pathology as well as several other pathological processes including modulation of glutamatergic function and inflammatory processes....

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Udgivet i:J Neuroinflammation
Main Authors: Brownell, Anna-Liisa, Kuruppu, Darshini, Kil, Kun-Eek, Jokivarsi, Kimmo, Poutiainen, Pekka, Zhu, Aijun, Maxwell, Michelle
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657381/
https://ncbi.nlm.nih.gov/pubmed/26597638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0439-9
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