Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

3′-Hydroxyacetanilide or N-acetyl-meta-aminophenol (AMAP) is generally regarded as a non-hepatotoxic analog of acetaminophen (APAP). Previous studies demonstrated absence of toxicity after AMAP in mice, hamsters, primary mouse hepatocytes and several cell lines. In contrast, experiments with liver s...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Xie, Yuchao, McGill, Mitchell R., Du, Kuo, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Ding, Wen-Xing, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651811/
https://ncbi.nlm.nih.gov/pubmed/26431796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.09.022
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