Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

3′-Hydroxyacetanilide or N-acetyl-meta-aminophenol (AMAP) is generally regarded as a non-hepatotoxic analog of acetaminophen (APAP). Previous studies demonstrated absence of toxicity after AMAP in mice, hamsters, primary mouse hepatocytes and several cell lines. In contrast, experiments with liver s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Appl Pharmacol
Prif Awduron: Xie, Yuchao, McGill, Mitchell R., Du, Kuo, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Ding, Wen-Xing, Jaeschke, Hartmut
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651811/
https://ncbi.nlm.nih.gov/pubmed/26431796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.09.022
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