Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)

JAK (Janus family of cytoplasmic tyrosine kinases) family tyrosine kinase 2 (TYK2) participates in signaling through cytokine receptors involved in immune responses and inflammation. JAKs are characterized by dual kinase domain: a tyrosine kinase domain (JH1) that is preceded by a pseudokinase domai...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Min, Xiaoshan, Ungureanu, Daniela, Maxwell, Sarah, Hammarén, Henrik, Thibault, Steve, Hillert, Ellin-Kristina, Ayres, Merrill, Greenfield, Brad, Eksterowicz, John, Gabel, Chris, Walker, Nigel, Silvennoinen, Olli, Wang, Zhulun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646372/
https://ncbi.nlm.nih.gov/pubmed/26359499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672048
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