Proteome Imbalance is Linked With Proteostasis Decline and Aggregation in Aging C. elegans

Aging has been associated with a progressive decline of proteostasis, but how this process manifests itself at the level of proteome composition remains largely unexplored. Here we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one third of proteins cha...

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Publicado en:Cell
Autores principales: Walther, Dirk M., Kasturi, Prasad, Zheng, Min, Pinkert, Stefan, Vecchi, Giulia, Ciryam, Prajwal, Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele, Mann, Matthias, Hartl, F.-Ulrich
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643853/
https://ncbi.nlm.nih.gov/pubmed/25957690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.03.032
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