Proteome Imbalance is Linked With Proteostasis Decline and Aggregation in Aging C. elegans

Aging has been associated with a progressive decline of proteostasis, but how this process manifests itself at the level of proteome composition remains largely unexplored. Here we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one third of proteins cha...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Walther, Dirk M., Kasturi, Prasad, Zheng, Min, Pinkert, Stefan, Vecchi, Giulia, Ciryam, Prajwal, Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele, Mann, Matthias, Hartl, F.-Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643853/
https://ncbi.nlm.nih.gov/pubmed/25957690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.03.032
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