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Proteome Imbalance is Linked With Proteostasis Decline and Aggregation in Aging C. elegans

Aging has been associated with a progressive decline of proteostasis, but how this process manifests itself at the level of proteome composition remains largely unexplored. Here we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one third of proteins cha...

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Bibliografische gegevens
Gepubliceerd in:Cell
Hoofdauteurs: Walther, Dirk M., Kasturi, Prasad, Zheng, Min, Pinkert, Stefan, Vecchi, Giulia, Ciryam, Prajwal, Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele, Mann, Matthias, Hartl, F.-Ulrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643853/
https://ncbi.nlm.nih.gov/pubmed/25957690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.03.032
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