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A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify a...
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| Опубликовано в: : | Sci Adv |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Association for the Advancement of Science
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980108/ https://ncbi.nlm.nih.gov/pubmed/27532054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600947 |
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