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A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease

In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify a...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Freer, Rosie, Sormanni, Pietro, Vecchi, Giulia, Ciryam, Prajwal, Dobson, Christopher M., Vendruscolo, Michele
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980108/
https://ncbi.nlm.nih.gov/pubmed/27532054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600947
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