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A Cell- and Tissue-Specific Weakness of the Protein Homeostasis System Underlies Brain Vulnerability to Protein Aggregation

The phenomenon of protein misfolding and aggregation is associated with a wide range of neurodegenerative conditions that cause progressive loss of function in specific regions of the human brain. To understand the causes of the selective cell and tissue vulnerability to the formation of these depos...

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Pubblicato in:iScience
Autori principali: Kundra, Rishika, Dobson, Christopher M., Vendruscolo, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063235/
https://ncbi.nlm.nih.gov/pubmed/32146327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100934
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