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A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify a...
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| 出版年: | Sci Adv |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Association for the Advancement of Science
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980108/ https://ncbi.nlm.nih.gov/pubmed/27532054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600947 |
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