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Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction
Thymidylate synthase (TSase) catalyzes the de novo biosynthesis of thymidylate, a precursor for DNA, and is thus an important target for chemotherapeutics and antibiotics. Two sequential C-H bond cleavages catalyzed by TSase are of particular interest: a reversible proton abstraction from the 2′-deo...
Tallennettuna:
| Julkaisussa: | ACS Catal |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643671/ https://ncbi.nlm.nih.gov/pubmed/26576323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.5b01332 |
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