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Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction
Thymidylate synthase (TSase) catalyzes the de novo biosynthesis of thymidylate, a precursor for DNA, and is thus an important target for chemotherapeutics and antibiotics. Two sequential C-H bond cleavages catalyzed by TSase are of particular interest: a reversible proton abstraction from the 2′-deo...
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| Vydáno v: | ACS Catal |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643671/ https://ncbi.nlm.nih.gov/pubmed/26576323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.5b01332 |
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