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Concerted versus Stepwise Mechanism in Thymidylate Synthase
[Image: see text] Thymidylate synthase (TSase) catalyzes the intracellular de novo formation of thymidylate (a DNA building block) in most living organisms, making it a common target for chemotherapeutic and antibiotic drugs. Two mechanisms have been proposed for the rate-limiting hydride transfer s...
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| Glavni autori: | , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
|
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4105062/ https://ncbi.nlm.nih.gov/pubmed/24949852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja504341g |
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