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Experimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer for E. coli Thymidylate Synthase

Thymidylate synthase (TSase), an enzyme responsible for the de novo biosynthesis of 2’-deoxythymidine 5’-monophosphate (thymidylate, dTMP) necessary for DNA synthesis, has been a drug target for decades. TSase is a highly conserved enzyme across species ranging from very primitive organisms to mamma...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Gurevic, Ilya, Islam, Zahidul, Świderek, Katarzyna, Trepka, Kai, Ghosh, Ananda K., Moliner, Vicent, Kohen, Amnon
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605054/
https://ncbi.nlm.nih.gov/pubmed/31275729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b02554
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