Effects of γ-secretase cleavage-region mutations on APP processing and Aβ formation: interpretation with sequential cleavage and α-helical model

Overwhelming evidence supports the amyloid hypothesis of Alzheimer’s disease that stipulates that the relative level of the 42 amino acid β-amyloid peptide (Aβ(42)) in relationship to Aβ(40) is critical to the pathogenesis of the disease. While it is clear that the multi-subunit gamma secretase is r...

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Bibliografiska uppgifter
I publikationen:J Neurochem
Huvudupphovsmän: Tan, Jianxin, Mao, Guozhang, Cui, Mei-Zhen, Kang, Shin-Chung, Lamb, Bruce, Wong, Boon-Seng, Sy, Man-Sun, Xu, Xuemin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633302/
https://ncbi.nlm.nih.gov/pubmed/18752644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05643.x
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