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Residues at P2-P1 positions of ε- and ζ-cleavage sites are important in formation of beta-amyloid peptide
Most of the Alzheimer’s disease (AD)-linked mutations in amyloid precursor protein (APP), which cause abnormal production of β-amyloid (Aβ), are localized at the major β-secretase- and γ-secretase cleavage sites. In this study, using an APP-knockout mouse neuronal cell line, our data demonstrated th...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3520095/ https://ncbi.nlm.nih.gov/pubmed/19716417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.08.010 |
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