BOTH THE N-TERMINAL FRAGMENT AND THE PROTEIN-PROTEIN INTERACTION DOMAIN (PDZ DOMAIN) ARE REQUIRED FOR THE PRO-APOPTOTIC ACTIVITY OF PRESENILIN-ASSOCIATED PROTEIN PSAP

Presenilin-associated protein (PSAP) was originally identified as a PS1-associated, PDZ domain protein. In a subsequent study, PSAP was found to be a mitochondrial apoptotic molecule. In this study, we cloned the PSAP gene and found that it is composed of 12 exons and localizes on chromosome 6. To b...

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Detalhes bibliográficos
Main Authors: Mao, Guozhang, Tan, Jianxin, Shi, Yongchang, Cui, Mei-Zhen, Xu, Xuemin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509497/
https://ncbi.nlm.nih.gov/pubmed/18291114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2008.01.013
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