PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs

NHE3 directly binds Na(+)/H(+) exchanger regulatory factor (NHERF) family scaffolding proteins that are required for many aspects of NHE3 regulation. The NHERFs bind both to an internal region (amino acids 586–660) of the NHE3 C terminus and to the NHE3 C-terminal four amino acids. The internal NHER...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cha, Boyoung, Yang, Jianbo, Singh, Varsha, Zachos, Nicholas C., Sarker, Rafiquel I., Chen, Tian-e, Chakraborty, Molee, Tse, Chung-Ming, Donowitz, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437235/
https://ncbi.nlm.nih.gov/pubmed/28283572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.774489
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