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Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity

Genetic determinants appear to play a role in susceptibility to chronic diarrhea, but the genetic abnormalities involved have only been identified in a few conditions. The Na(+)/H(+) exchanger 3 (NHE3) accounts for a large fraction of physiologic intestinal Na(+) absorption. It is highly regulated t...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Zhu, Xinjun Cindy, Sarker, Rafiquel, Horton, John R., Chakraborty, Molee, Chen, Tian-E, Tse, C. Ming, Cha, Boyoung, Donowitz, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420795/
https://ncbi.nlm.nih.gov/pubmed/25715704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00421.2014
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