Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes

Casein kinase 2 (CK2) binds to the NHE3 C-terminus and constitutively phosphorylates a downstream site (S719) that accounts for 40% of basal NHE3 activity. The role of CK2 in regulation of NHE3 activity in polarized Caco-2/bbe cells was further examined by mutation of NHE3-S(719) to A (not phosphory...

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Publicado en:Mol Biol Cell
Autores principales: Sarker, Rafiquel, Cha, Boyoung, Kovbasnjuk, Olga, Cole, Robert, Gabelli, Sandra, Tse, Chung Ming, Donowitz, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491184/
https://ncbi.nlm.nih.gov/pubmed/28495796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-12-0862
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