Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling

The Na(+)/H(+) exchanger 3 (NHE3) is a brush border (BB) Na(+)/H(+) antiporter that accounts for the majority of physiologic small intestinal and renal Na(+) absorption. It is regulated physiologically and in disease via changes in endocytosis/exocytosis. Paradoxically, NHE3 is fixed to the microvil...

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Main Authors: Cha, Boyoung, Chen, Tiane, Sarker, Rafiquel, Yang, Jianbo, Raben, Daniel, Tse, C. Ming, Kovbasnjuk, Olga, Donowitz, Mark
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080180/
https://ncbi.nlm.nih.gov/pubmed/24760985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00045.2014
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