Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na(+)/H(+) Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process

The epithelial brush border (BB) Na(+)/H(+) exchanger 3 (NHE3) accounts for most renal and intestinal Na(+) absorption. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibits NHE3 activity under basal conditions in intact intestine, acting in the BB, but the mechanism is unclear. We now dem...

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Autori principali: Zizak, Mirza, Chen, Tiane, Bartonicek, Dorotea, Sarker, Rafiquel, Zachos, Nicholas C., Cha, Boyoung, Kovbasnjuk, Olga, Korac, Jelena, Mohan, Sachin, Cole, Robert, Chen, Yueping, Tse, C. Ming, Donowitz, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340005/
https://ncbi.nlm.nih.gov/pubmed/22371496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.307256
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