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Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na(+)/H(+) Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process
The epithelial brush border (BB) Na(+)/H(+) exchanger 3 (NHE3) accounts for most renal and intestinal Na(+) absorption. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibits NHE3 activity under basal conditions in intact intestine, acting in the BB, but the mechanism is unclear. We now dem...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340005/ https://ncbi.nlm.nih.gov/pubmed/22371496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.307256 |
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