Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes. A natural ketolide pikromycin and a related compound methymycin are produced by Streptomyces vene...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Almutairi, Mashal M., Park, Sung Ryeol, Rose, Simon, Hansen, Douglas A., Vázquez-Laslop, Nora, Douthwaite, Stephen, Sherman, David H., Mankin, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620888/
https://ncbi.nlm.nih.gov/pubmed/26438831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512090112
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