Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide protein synthesis inhibitors. Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone ring of MTM and PKM. In addition...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Almutairi, Mashal M., Svetlov, Maxim S., Hansen, Douglas A., Khabibullina, Nelli F., Klepacki, Dorota, Kang, Han-Young, Sherman, David H., Vázquez-Laslop, Nora, Polikanov, Yury S., Mankin, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766166/
https://ncbi.nlm.nih.gov/pubmed/28934499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx673
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