Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

AIMS: Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and f...

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Detaylı Bibliyografya
Yayımlandı:Cardiovasc Res
Asıl Yazarlar: Liu, Bin, Ho, Hsiang-Ting, Brunello, Lucia, Unudurthi, Sathya D., Lou, Qing, Belevych, Andriy E., Qian, Lan, Kim, Do Han, Cho, Chunghee, Janssen, Paul M. L., Hund, Thomas J., Knollmann, Bjorn C., Kranias, Evangelia G., Györke, Sándor
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2015
Konular:
ORIGINAL ARTICLES
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614688/
https://ncbi.nlm.nih.gov/pubmed/26410369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv222
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