A Mutation in Calsequestrin, CASQ2(D307H), Impairs Sarcoplasmic Reticulum Ca(2+) Handling and Causes Complex Ventricular Arrhythmias in Mice

OBJECTIVE: A naturally-occurring mutation in cardiac calsequestrin (CASQ2) at amino acid 307 was discovered in a highly inbred family and hypothesized to cause Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). The goal of this study was to establish a causal link between CASQ2(D307H) and...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dirksen, Wessel P., Lacombe, Veronique A., Chi, Mei, Kalyanasundaram, Anuradha, Viatchenko-Karpinski, Serge, Terentyev, Dmitry, Zhou, Zhixiang, Vedamoorthyrao, Srikanth, Li, Ning, Chiamvimonvat, Nipavan, Carnes, Cynthia A., Franzini-Armstrong, Clara, Györke, Sandor, Periasamy, Muthu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717009/
https://ncbi.nlm.nih.gov/pubmed/17449018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardiores.2007.03.002
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares